Three mutations switch H7N9 influenza to human-type receptor specificity
Identifieur interne : 000017 ( 1957/Analysis ); précédent : 000016; suivant : 000018Three mutations switch H7N9 influenza to human-type receptor specificity
Auteurs : Robert P. De Vries [États-Unis, Pays-Bas] ; Wenjie Peng [États-Unis] ; Oliver C. Grant [États-Unis] ; Andrew J. Thompson [États-Unis] ; Xueyong Zhu [États-Unis] ; Kim M. Bouwman [Pays-Bas] ; Alba T. Torrents De La Pena [Pays-Bas] ; Marielle J. Van Breemen [Pays-Bas] ; Iresha N. Ambepitiya Wickramasinghe [Pays-Bas] ; Cornelis A. M. De Haan [Pays-Bas] ; Wenli Yu [États-Unis] ; Ryan Mcbride [États-Unis] ; Rogier W. Sanders [Pays-Bas, États-Unis] ; Robert J. Woods [États-Unis] ; Monique H. Verheije [Pays-Bas] ; Ian A. Wilson [États-Unis] ; James C. Paulson [États-Unis]Source :
- PLoS Pathogens [ 1553-7366 ] ; 2017.
Descripteurs français
- KwdFr :
- Alignement de séquences, Animaux, Données de séquences moléculaires, Glycoprotéine hémagglutinine du virus influenza (), Glycoprotéine hémagglutinine du virus influenza (génétique), Glycoprotéine hémagglutinine du virus influenza (métabolisme), Grippe chez les oiseaux (génétique), Grippe chez les oiseaux (métabolisme), Grippe chez les oiseaux (virologie), Grippe humaine (génétique), Grippe humaine (métabolisme), Grippe humaine (virologie), Humains, Liaison aux protéines, Maladies de la volaille (génétique), Maladies de la volaille (métabolisme), Maladies de la volaille (virologie), Mutation, Récepteurs viraux (génétique), Récepteurs viraux (métabolisme), Sous-type H3N2 du virus de la grippe A (), Sous-type H3N2 du virus de la grippe A (génétique), Sous-type H3N2 du virus de la grippe A (métabolisme), Sous-type H7N9 du virus de la grippe A (), Sous-type H7N9 du virus de la grippe A (génétique), Sous-type H7N9 du virus de la grippe A (métabolisme), Spécificité d'hôte, Séquence d'acides aminés, Volaille.
- MESH :
- génétique : Glycoprotéine hémagglutinine du virus influenza, Grippe chez les oiseaux, Grippe humaine, Maladies de la volaille, Récepteurs viraux, Sous-type H3N2 du virus de la grippe A, Sous-type H7N9 du virus de la grippe A.
- métabolisme : Glycoprotéine hémagglutinine du virus influenza, Grippe chez les oiseaux, Grippe humaine, Maladies de la volaille, Récepteurs viraux, Sous-type H3N2 du virus de la grippe A, Sous-type H7N9 du virus de la grippe A.
- virologie : Grippe chez les oiseaux, Grippe humaine, Maladies de la volaille.
- Alignement de séquences, Animaux, Données de séquences moléculaires, Glycoprotéine hémagglutinine du virus influenza, Humains, Liaison aux protéines, Mutation, Sous-type H3N2 du virus de la grippe A, Sous-type H7N9 du virus de la grippe A, Spécificité d'hôte, Séquence d'acides aminés, Volaille.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Hemagglutinin Glycoproteins, Influenza Virus (chemistry), Hemagglutinin Glycoproteins, Influenza Virus (genetics), Hemagglutinin Glycoproteins, Influenza Virus (metabolism), Host Specificity, Humans, Influenza A Virus, H3N2 Subtype (chemistry), Influenza A Virus, H3N2 Subtype (genetics), Influenza A Virus, H3N2 Subtype (metabolism), Influenza A Virus, H7N9 Subtype (chemistry), Influenza A Virus, H7N9 Subtype (genetics), Influenza A Virus, H7N9 Subtype (metabolism), Influenza in Birds (genetics), Influenza in Birds (metabolism), Influenza in Birds (virology), Influenza, Human (genetics), Influenza, Human (metabolism), Influenza, Human (virology), Molecular Sequence Data, Mutation, Poultry, Poultry Diseases (genetics), Poultry Diseases (metabolism), Poultry Diseases (virology), Protein Binding, Receptors, Virus (genetics), Receptors, Virus (metabolism), Sequence Alignment.
- MESH :
- chemical , chemistry : Hemagglutinin Glycoproteins, Influenza Virus.
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus, Receptors, Virus.
- chemical , metabolism : Hemagglutinin Glycoproteins, Influenza Virus, Receptors, Virus.
- chemistry : Influenza A Virus, H3N2 Subtype, Influenza A Virus, H7N9 Subtype.
- genetics : Influenza A Virus, H3N2 Subtype, Influenza A Virus, H7N9 Subtype, Influenza in Birds, Influenza, Human, Poultry Diseases.
- metabolism : Influenza A Virus, H3N2 Subtype, Influenza A Virus, H7N9 Subtype, Influenza in Birds, Influenza, Human, Poultry Diseases.
- virology : Influenza in Birds, Influenza, Human, Poultry Diseases.
- Amino Acid Sequence, Animals, Host Specificity, Humans, Molecular Sequence Data, Mutation, Poultry, Protein Binding, Sequence Alignment.
Abstract
The avian H7N9 influenza outbreak in 2013 resulted from an unprecedented incidence of influenza transmission to humans from infected poultry. The majority of human H7N9 isolates contained a hemagglutinin (HA) mutation (Q226L) that has previously been associated with a switch in receptor specificity from avian-type (NeuAcα2-3Gal) to human-type (NeuAcα2-6Gal), as documented for the avian progenitors of the 1957 (H2N2) and 1968 (H3N2) human influenza pandemic viruses. While this raised concern that the H7N9 virus was adapting to humans, the mutation was not sufficient to switch the receptor specificity of H7N9, and has not resulted in sustained transmission in humans. To determine if the H7 HA was capable of acquiring human-type receptor specificity, we conducted mutation analyses. Remarkably, three amino acid mutations conferred a switch in specificity for human-type receptors that resembled the specificity of the 2009 human H1 pandemic virus, and promoted binding to human trachea epithelial cells.
Url:
DOI: 10.1371/journal.ppat.1006390
PubMed: 28617868
PubMed Central: 5472306
Affiliations:
- Pays-Bas, États-Unis
- Californie, Géorgie (États-Unis), Hollande-Septentrionale, Utrecht (province), État de New York
- Amsterdam, Utrecht
- Université d'Amsterdam, Université d'Utrecht
Links toward previous steps (curation, corpus...)
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Links to Exploration step
PMC:5472306Le document en format XML
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Woods</name><affiliation wicri:level="2"><nlm:aff id="aff003"><addr-line>Complex Carbohydrate Research Center, University of Georgia, Athens, GA, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Complex Carbohydrate Research Center, University of Georgia, Athens, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Verheije, Monique H" sort="Verheije, Monique H" uniqKey="Verheije M" first="Monique H." last="Verheije">Monique H. 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De Vries</name><affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>Departments of Molecular Medicine, & Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Molecular Medicine, & Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff002"><addr-line>Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, CG Utrecht, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, CG Utrecht</wicri:regionArea><orgName type="university">Université d'Utrecht</orgName><placeName><settlement type="city">Utrecht</settlement><region nuts="2">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Peng, Wenjie" sort="Peng, Wenjie" uniqKey="Peng W" first="Wenjie" last="Peng">Wenjie Peng</name><affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>Departments of Molecular Medicine, & Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Molecular Medicine, & Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Grant, Oliver C" sort="Grant, Oliver C" uniqKey="Grant O" first="Oliver C." last="Grant">Oliver C. Grant</name><affiliation wicri:level="2"><nlm:aff id="aff003"><addr-line>Complex Carbohydrate Research Center, University of Georgia, Athens, GA, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Complex Carbohydrate Research Center, University of Georgia, Athens, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Thompson, Andrew J" sort="Thompson, Andrew J" uniqKey="Thompson A" first="Andrew J." last="Thompson">Andrew J. Thompson</name><affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>Departments of Molecular Medicine, & Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Molecular Medicine, & Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Zhu, Xueyong" sort="Zhu, Xueyong" uniqKey="Zhu X" first="Xueyong" last="Zhu">Xueyong Zhu</name><affiliation wicri:level="2"><nlm:aff id="aff004"><addr-line>Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bouwman, Kim M" sort="Bouwman, Kim M" uniqKey="Bouwman K" first="Kim M." last="Bouwman">Kim M. Bouwman</name><affiliation wicri:level="4"><nlm:aff id="aff005"><addr-line>Pathology Division, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, CL Utrecht, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Pathology Division, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, CL Utrecht</wicri:regionArea><orgName type="university">Université d'Utrecht</orgName><placeName><settlement type="city">Utrecht</settlement><region nuts="2">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="De La Pena, Alba T Torrents" sort="De La Pena, Alba T Torrents" uniqKey="De La Pena A" first="Alba T. Torrents" last="De La Pena">Alba T. Torrents De La Pena</name><affiliation wicri:level="4"><nlm:aff id="aff006"><addr-line>Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, AZ Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, AZ Amsterdam</wicri:regionArea><orgName type="university">Université d'Amsterdam</orgName><placeName><settlement type="city">Amsterdam</settlement><region>Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Van Breemen, Marielle J" sort="Van Breemen, Marielle J" uniqKey="Van Breemen M" first="Marielle J." last="Van Breemen">Marielle J. Van Breemen</name><affiliation wicri:level="4"><nlm:aff id="aff006"><addr-line>Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, AZ Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, AZ Amsterdam</wicri:regionArea><orgName type="university">Université d'Amsterdam</orgName><placeName><settlement type="city">Amsterdam</settlement><region>Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Ambepitiya Wickramasinghe, Iresha N" sort="Ambepitiya Wickramasinghe, Iresha N" uniqKey="Ambepitiya Wickramasinghe I" first="Iresha N." last="Ambepitiya Wickramasinghe">Iresha N. Ambepitiya Wickramasinghe</name><affiliation wicri:level="4"><nlm:aff id="aff005"><addr-line>Pathology Division, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, CL Utrecht, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Pathology Division, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, CL Utrecht</wicri:regionArea><orgName type="university">Université d'Utrecht</orgName><placeName><settlement type="city">Utrecht</settlement><region nuts="2">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="De Haan, Cornelis A M" sort="De Haan, Cornelis A M" uniqKey="De Haan C" first="Cornelis A. M." last="De Haan">Cornelis A. M. De Haan</name><affiliation wicri:level="4"><nlm:aff id="aff007"><addr-line>Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1,CL Utrecht, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1,CL Utrecht</wicri:regionArea><orgName type="university">Université d'Utrecht</orgName><placeName><settlement type="city">Utrecht</settlement><region nuts="2">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Yu, Wenli" sort="Yu, Wenli" uniqKey="Yu W" first="Wenli" last="Yu">Wenli Yu</name><affiliation wicri:level="2"><nlm:aff id="aff004"><addr-line>Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mcbride, Ryan" sort="Mcbride, Ryan" uniqKey="Mcbride R" first="Ryan" last="Mcbride">Ryan Mcbride</name><affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>Departments of Molecular Medicine, & Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Molecular Medicine, & Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Sanders, Rogier W" sort="Sanders, Rogier W" uniqKey="Sanders R" first="Rogier W." last="Sanders">Rogier W. Sanders</name><affiliation wicri:level="4"><nlm:aff id="aff006"><addr-line>Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, AZ Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, AZ Amsterdam</wicri:regionArea><orgName type="university">Université d'Amsterdam</orgName><placeName><settlement type="city">Amsterdam</settlement><region>Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff008"><addr-line>Department of Microbiology and Immunology, Weil Medical College of Cornell University, New York, NY, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Weil Medical College of Cornell University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Woods, Robert J" sort="Woods, Robert J" uniqKey="Woods R" first="Robert J." last="Woods">Robert J. Woods</name><affiliation wicri:level="2"><nlm:aff id="aff003"><addr-line>Complex Carbohydrate Research Center, University of Georgia, Athens, GA, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Complex Carbohydrate Research Center, University of Georgia, Athens, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Verheije, Monique H" sort="Verheije, Monique H" uniqKey="Verheije M" first="Monique H." last="Verheije">Monique H. Verheije</name><affiliation wicri:level="4"><nlm:aff id="aff005"><addr-line>Pathology Division, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, CL Utrecht, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Pathology Division, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, CL Utrecht</wicri:regionArea><orgName type="university">Université d'Utrecht</orgName><placeName><settlement type="city">Utrecht</settlement><region nuts="2">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Wilson, Ian A" sort="Wilson, Ian A" uniqKey="Wilson I" first="Ian A." last="Wilson">Ian A. Wilson</name><affiliation wicri:level="2"><nlm:aff id="aff004"><addr-line>Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff009"><addr-line>Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Paulson, James C" sort="Paulson, James C" uniqKey="Paulson J" first="James C." last="Paulson">James C. Paulson</name><affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>Departments of Molecular Medicine, & Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Molecular Medicine, & Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">PLoS Pathogens</title><idno type="ISSN">1553-7366</idno><idno type="eISSN">1553-7374</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Hemagglutinin Glycoproteins, Influenza Virus (chemistry)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (genetics)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (metabolism)</term><term>Host Specificity</term><term>Humans</term><term>Influenza A Virus, H3N2 Subtype (chemistry)</term><term>Influenza A Virus, H3N2 Subtype (genetics)</term><term>Influenza A Virus, H3N2 Subtype (metabolism)</term><term>Influenza A Virus, H7N9 Subtype (chemistry)</term><term>Influenza A Virus, H7N9 Subtype (genetics)</term><term>Influenza A Virus, H7N9 Subtype (metabolism)</term><term>Influenza in Birds (genetics)</term><term>Influenza in Birds (metabolism)</term><term>Influenza in Birds (virology)</term><term>Influenza, Human (genetics)</term><term>Influenza, Human (metabolism)</term><term>Influenza, Human (virology)</term><term>Molecular Sequence Data</term><term>Mutation</term><term>Poultry</term><term>Poultry Diseases (genetics)</term><term>Poultry Diseases (metabolism)</term><term>Poultry Diseases (virology)</term><term>Protein Binding</term><term>Receptors, Virus (genetics)</term><term>Receptors, Virus (metabolism)</term><term>Sequence Alignment</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences</term><term>Animaux</term><term>Données de séquences moléculaires</term><term>Glycoprotéine hémagglutinine du virus influenza ()</term><term>Glycoprotéine hémagglutinine du virus influenza (génétique)</term><term>Glycoprotéine hémagglutinine du virus influenza (métabolisme)</term><term>Grippe chez les oiseaux (génétique)</term><term>Grippe chez les oiseaux (métabolisme)</term><term>Grippe chez les oiseaux (virologie)</term><term>Grippe humaine (génétique)</term><term>Grippe humaine (métabolisme)</term><term>Grippe humaine (virologie)</term><term>Humains</term><term>Liaison aux protéines</term><term>Maladies de la volaille (génétique)</term><term>Maladies de la volaille (métabolisme)</term><term>Maladies de la volaille (virologie)</term><term>Mutation</term><term>Récepteurs viraux (génétique)</term><term>Récepteurs viraux (métabolisme)</term><term>Sous-type H3N2 du virus de la grippe A ()</term><term>Sous-type H3N2 du virus de la grippe A (génétique)</term><term>Sous-type H3N2 du virus de la grippe A (métabolisme)</term><term>Sous-type H7N9 du virus de la grippe A ()</term><term>Sous-type H7N9 du virus de la grippe A (génétique)</term><term>Sous-type H7N9 du virus de la grippe A (métabolisme)</term><term>Spécificité d'hôte</term><term>Séquence d'acides aminés</term><term>Volaille</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Receptors, Virus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Receptors, Virus</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza A Virus, H7N9 Subtype</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza A Virus, H7N9 Subtype</term><term>Influenza in Birds</term><term>Influenza, Human</term><term>Poultry Diseases</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Grippe chez les oiseaux</term><term>Grippe humaine</term><term>Maladies de la volaille</term><term>Récepteurs viraux</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Sous-type H7N9 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza A Virus, H7N9 Subtype</term><term>Influenza in Birds</term><term>Influenza, Human</term><term>Poultry Diseases</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Grippe chez les oiseaux</term><term>Grippe humaine</term><term>Maladies de la volaille</term><term>Récepteurs viraux</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Sous-type H7N9 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe chez les oiseaux</term><term>Grippe humaine</term><term>Maladies de la volaille</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza in Birds</term><term>Influenza, Human</term><term>Poultry Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Host Specificity</term><term>Humans</term><term>Molecular Sequence Data</term><term>Mutation</term><term>Poultry</term><term>Protein Binding</term><term>Sequence Alignment</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Alignement de séquences</term><term>Animaux</term><term>Données de séquences moléculaires</term><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Humains</term><term>Liaison aux protéines</term><term>Mutation</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Sous-type H7N9 du virus de la grippe A</term><term>Spécificité d'hôte</term><term>Séquence d'acides aminés</term><term>Volaille</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The avian H7N9 influenza outbreak in 2013 resulted from an unprecedented incidence of influenza transmission to humans from infected poultry. The majority of human H7N9 isolates contained a hemagglutinin (HA) mutation (Q226L) that has previously been associated with a switch in receptor specificity from avian-type (NeuAcα2-3Gal) to human-type (NeuAcα2-6Gal), as documented for the avian progenitors of the 1957 (H2N2) and 1968 (H3N2) human influenza pandemic viruses. While this raised concern that the H7N9 virus was adapting to humans, the mutation was not sufficient to switch the receptor specificity of H7N9, and has not resulted in sustained transmission in humans. To determine if the H7 HA was capable of acquiring human-type receptor specificity, we conducted mutation analyses. Remarkably, three amino acid mutations conferred a switch in specificity for human-type receptors that resembled the specificity of the 2009 human H1 pandemic virus, and promoted binding to human trachea epithelial cells.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Liang, W" uniqKey="Liang W">W Liang</name></author><author><name sortKey="Yang, S" uniqKey="Yang S">S Yang</name></author><author><name sortKey="Wu, N" uniqKey="Wu N">N Wu</name></author><author><name sortKey="Gao, H" uniqKey="Gao H">H Gao</name></author><author><name sortKey="Sheng, J" uniqKey="Sheng J">J Sheng</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Hu, J" uniqKey="Hu J">J Hu</name></author><author><name sortKey="Zhu, Y" uniqKey="Zhu Y">Y Zhu</name></author><author><name sortKey="Zhao, B" uniqKey="Zhao B">B 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Wilson</name><name sortKey="Wilson, Ian A" sort="Wilson, Ian A" uniqKey="Wilson I" first="Ian A." last="Wilson">Ian A. Wilson</name><name sortKey="Woods, Robert J" sort="Woods, Robert J" uniqKey="Woods R" first="Robert J." last="Woods">Robert J. Woods</name><name sortKey="Yu, Wenli" sort="Yu, Wenli" uniqKey="Yu W" first="Wenli" last="Yu">Wenli Yu</name><name sortKey="Zhu, Xueyong" sort="Zhu, Xueyong" uniqKey="Zhu X" first="Xueyong" last="Zhu">Xueyong Zhu</name></country><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="De Vries, Robert P" sort="De Vries, Robert P" uniqKey="De Vries R" first="Robert P." last="De Vries">Robert P. De Vries</name></region><name sortKey="Ambepitiya Wickramasinghe, Iresha N" sort="Ambepitiya Wickramasinghe, Iresha N" uniqKey="Ambepitiya Wickramasinghe I" first="Iresha N." last="Ambepitiya Wickramasinghe">Iresha N. Ambepitiya Wickramasinghe</name><name sortKey="Bouwman, Kim M" sort="Bouwman, Kim M" uniqKey="Bouwman K" first="Kim M." last="Bouwman">Kim M. Bouwman</name><name sortKey="De Haan, Cornelis A M" sort="De Haan, Cornelis A M" uniqKey="De Haan C" first="Cornelis A. M." last="De Haan">Cornelis A. M. De Haan</name><name sortKey="De La Pena, Alba T Torrents" sort="De La Pena, Alba T Torrents" uniqKey="De La Pena A" first="Alba T. Torrents" last="De La Pena">Alba T. Torrents De La Pena</name><name sortKey="Sanders, Rogier W" sort="Sanders, Rogier W" uniqKey="Sanders R" first="Rogier W." last="Sanders">Rogier W. Sanders</name><name sortKey="Van Breemen, Marielle J" sort="Van Breemen, Marielle J" uniqKey="Van Breemen M" first="Marielle J." last="Van Breemen">Marielle J. Van Breemen</name><name sortKey="Verheije, Monique H" sort="Verheije, Monique H" uniqKey="Verheije M" first="Monique H." last="Verheije">Monique H. 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|type= RBID
|clé= PMC:5472306
|texte= Three mutations switch H7N9 influenza to human-type receptor specificity
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/1957/Analysis/RBID.i -Sk "pubmed:28617868" \
| HfdSelect -Kh $EXPLOR_AREA/Data/1957/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |